Understanding Alzheimer’s Disease

Dr Aparna Vijay Kumar
September 20, 2020

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Alzheimer’s disease is a common cause of dementia. Dementia is a general term for loss of memory. Along with loss of short term memory, individuals develop loss of reasoning and thinking; as well as behaviour disturbances.

It is not just a disease of old age, though, it is often seen above 65 years of age. In less than 10% of cases, it is seen in patients between 40 to 60 years of age. It starts with difficulty in learning new things which shows impact on working memory, getting lost in familiar places followed by forgetting people, emotional and behavioural disturbances subsequently leading to a mute, bed bound state.

It is due to death of brain cells or neurons in memory area of the brain causing loss of connectivity with other neurons by the deposition of abnormal protein beta amyloid and tau. What causes this formation of protein is still under research. A combination of genetic, environmental and lifestyle factors is implicated.

The presence of apolipoprotein gene (APOE ) increases the risk but neither all individuals with the gene develop the disease nor all individuals with Alzheimer’s disease have this gene. Presence of metabolic conditions like diabetes, hypertension, heart disease, obesity, obstructive sleep apnea; diet and level of physical and mental activity also are implicated.

Diagnosis is only by clinical history and neurological examination. Imaging like SPECT, PET and MRI brain help in confirmation and ruling out treatable causes of dementia.

It is a slowly progressive disease with no cure as brain cells do not regenerate. Treatment with drugs aims at controlling the symptoms and slowing the progression by regulating the level of neurotransmitters or chemicals.

Care givers have a very challenging and important role in management of patients as caring of a person with Alzheimer’s disease causes physical and financial burden. Care givers also need support to cope up with the stress of handling their loved ones.

The take home message is that a healthy diet and regular exercise early on in life reduces the risk of Alzheimer’s disease. Healthy diet and regular exercise also prevent life style diseases like diabetes, hypertension, obesity and heart problems. Regular walking increases the level of a chemical brain derived neurotrophic factor( BNF) which potentiates memory.

A Mediterranean style of diet rich in fresh fruits and vegetables, nuts, legumes, olive oil has been shown to prevent the progression of disease in patients with minimal cognitive decline, a precursor of Alzheimer’s disease. Diet rich in curcumin, omega-3 fatty acids and cocoa have proven benefits with vitamin B12,D, E  and folate supplements.

 

Dr Aparna Vijay Kumar Senior Neurologist, Citizens Specialty Hospital

Comments

S C Sharma
 - 
Tuesday, 22 Sep 2020

Very informative article explaining in simplest language.

rmangala raman
 - 
Monday, 21 Sep 2020

Highly informative beneficial and clearly simplified to reach common man. Thank you.

S.Bhagyam Sharma
 - 
Monday, 21 Sep 2020

Very good information thank you very much Dr Aparna

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News Network
March 1,2025

The Trump administration has given the go-ahead for a nearly $3 billion arms sale to Israel, sidestepping the standard congressional review process to expedite the delivery of 2,000-pound bombs widely used by the Israeli military in its ongoing onslaught in the Gaza Strip.

In a series of notifications sent to Congress on Friday, the State Department has reported it has approved the sale of more than 35,500 MK 84 and BLU-117 bombs and 4,000 Predator warheads worth $2.04 billion to Israel.

Secretary of State Marco Rubio “has determined and provided detailed justification that an emergency exists that requires the immediate sale to the Government of Israel of the above defense articles and defense services in the national security interests of the United States, thereby waiving the Congressional review requirements,” the department said.

Deliveries are set to begin next year, it said.

According to the same statement, Rubio has also approved another munitions sale to Israel worth $675.7 million to be delivered starting in 2028.

The Israeli regime has extensively used the MK 84, also known as the 2,000-pound bomb, in its genocidal wars against the people of Lebanon and Palestine, including the assassination of top Hamas and Hezbollah leaders.

Last May, the previous US administration attempted to curb Israel’s military aggression in Rafah, a city in southern Gaza, by imposing a temporary ban on the sale of 2,000-pound bombs.

This effort, however, proved futile in halting the invasion, as the US continued to supply other weapons to the Israeli regime.

On February 25, Trump’s National Security Adviser, Michael Waltz, rescinded the ban to allow the State Department to resume the sale of the bombs to the regime.

The State Department has also approved the sale of Caterpillar D9 Bulldozers and related equipment for an estimated cost of $295 million to Israel.

The Israeli regime has used D9 bulldozers to demolish thousands of Palestinian homes in the occupied West Bank and Gaza.

The Office of the UN High Commissioner on Human Rights has advised Caterpillar Inc. that by supplying the bulldozers to the regime, it is complicit in human rights violations.

D9 has been involved in several incidents of civilian deaths, including in 2023 when it was used against the refugees sheltering outside the Kamal Adwan Hospital.

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coastaldigest.com news network
March 3,2025

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In a significant policy shift, the central government has amended the passport application process, making birth certificates the sole valid proof of date of birth for individuals born on or after October 1, 2023. This move aims to streamline documentation and ensure uniformity in age verification.

Mandatory Birth Certificate for New Applicants

The new rule, announced last week as part of the amended Passport Rules, will take effect after its publication in the official Gazette. As per a notification dated February 24, the Ministry of External Affairs has revised the requirements for submitting proof of date of birth when applying for a passport.

For individuals born on or after October 1, 2023, only birth certificates issued by the Municipal Corporation, the Registrar of Births and Deaths, or any other authorized body under the Registration of Births and Deaths Act, 1969, will be accepted as valid proof of date of birth.

However, those born before this date can continue to submit alternative documents, including school transfer certificates, matriculation certificates, PAN cards, driving licenses, or extracts from service records.

Changes in Residential Information

To enhance privacy, applicants’ residential addresses will no longer be printed on the final page of passports. Instead, immigration officers will retrieve this information by scanning an embedded barcode.

New Colour-Coded Passports

The government has also introduced a colour-coding system for passports:

  • White passports for government officials
  • Red passports for diplomats
  • Blue passports for ordinary citizens

Parental Information No Longer Required

Another major change is the removal of parents' names from the last page of the passport. This revision is aimed at protecting personal information, particularly for individuals from separated or split families.

Expansion of Passport Seva Kendras

To enhance accessibility, the government plans to increase the number of Post Office Passport Seva Kendras (POPSKs) from 442 to 600 over the next five years. The Department of Posts and the Ministry of External Affairs (MEA) have extended their Memorandum of Understanding (MoU) to facilitate this expansion, ensuring continued passport services at POPSKs.

Officials noted that passport rules regarding date of birth had not been updated for a long time, largely because many rural residents lacked birth certificates. However, with stricter enforcement of the Registration of Births and Deaths Act, 1969, birth certificates have now become the only recognized proof for those born after October 1, 2023.

These sweeping changes mark a significant update in India’s passport application process, reinforcing security, privacy, and efficiency in document verification.

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Media Release
March 5,2025

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New Delhi: Former U.S. President Donald Trump has announced plans to develop a state-of-the-art missile defense system called the ‘Golden Dome’, inspired by Israel’s ‘Iron Dome.’ Addressing a joint session of Congress, Trump declared his intention to build “the most powerful military of the future” and pledged funding for a comprehensive missile shield to protect the U.S. homeland.

A Modern Take on Reagan’s Vision

Trump claimed that former President Ronald Reagan had envisioned a similar system decades ago but lacked the technology to bring it to life. The initiative he referred to was the Strategic Defense Initiative (SDI) of the 1980s, which aimed to intercept intercontinental ballistic missiles (ICBMs) but was eventually abandoned following the collapse of the Soviet Union.

How Will the ‘Golden Dome’ Work?

The U.S. already has several missile defense systems in place. Trump’s ‘Golden Dome’ would likely integrate existing technologies, including:

🔹 Space-Based Infrared System (SBIRS) – Satellites that provide early missile launch warnings.

🔹 Ground-Based Midcourse Defense (GMD) – Interceptors in Alaska and California designed to shoot down ICBMs.

🔹 Aegis Ballistic Missile Defense (BMD) – A naval-based system for intercepting short- to intermediate-range missiles.

🔹 Terminal High Altitude Area Defense (THAAD) – A mobile system to destroy medium- and intermediate-range missiles.

🔹 Patriot Advanced Capability-3 (PAC-3) – Interceptor missiles designed to counter Chinese hypersonic threats.

Comparing with Israel’s ‘Iron Dome’

Israel’s multi-layered missile defense includes:

✅ Iron Dome – Protects against short-range rockets.
✅ David’s Sling – Targets mid- to long-range missiles.
✅ Arrow-2 and Arrow-3 – Designed to intercept long-range ballistic missiles.

With the U.S. contributing over $3.7 billion toward Israel’s Arrow defense system, Trump’s ‘Golden Dome’ could follow a similar model but on a much larger scale.

While the feasibility and timeline of this ambitious project remain unclear, Trump's announcement signals a renewed push for advanced missile defense in an increasingly volatile world.

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