Here’s what we know about BA.2, the sister of Omicron

Agencies
February 3, 2022

Cases of the SARS-CoV-2 variant Omicron have escalated globally over the past two months, with many countries experiencing peaks higher than previous variants.

Now we’re seeing cases of a sub-variant of Omicron, known as BA.2, emerge in Australia and more than 50 countries.

Rather than a daughter of the Omicron variant BA.1 (or B.1.1.529), it’s more helpful to think of BA.2 as Omicron’s sister.

Remind me, what is a variant?

Viruses, and particularly RNA viruses such as SARS-CoV-2, make lots of mistakes when they reproduce. They can’t correct these mistakes, so they have a relatively high rate of errors, or mutations, and are constantly evolving.

When the genetic code of a virus changes as a result of these mutations, it’s referred to as a variant.

Omicron is a “highly divergent” variant, having accumulated more than 30 mutations in the spike protein. This has reduced the protection of antibodies from both prior infection and vaccination, and increased transmissibility.

When do health authorities worry about a new variant?

If changes in the genetic code are thought to have the potential to impact properties of the virus that make it more harmful, and there’s significant transmission in multiple countries, it will be deemed a “variant of interest”.

If a variant of interest is then shown to be more infectious, evade protection from vaccination or previous infection, and/or impact the performance of tests or treatments, it is labelled a “variant of concern”.

The World Health Organization (WHO) classified Omicron a variant of concern on November 26 because of its potential to cause higher reinfection rates, increased transmissibility and reduced vaccine protection.

What is the Omicron lineage?

A lineage, or sub-variant, is a genetically closely related group of virus variants derived from a common ancestor.

The Omicron variant comprises three sub-lineages: B.1.1.529 or BA.1, BA.2 and BA.3.

While the WHO has not given BA.2 a separate classification, the United Kingdom has labelled BA.2 a variant “under investigation”. So not yet a variant of interest or concern, based on WHO definitions, but one that is being watched closely.

This is not the first variant to have sub-lineages. Late last year, Delta “plus” or AY.4.2 was reported widely, then Omicron came along.

What’s different about BA.2?

While the first sequences of BA.2 were submitted from the Philippines – and we have now seen thousands of cases, including in the United States, the UK and some in Australia – its origin is still unknown.

The exact properties of BA.2 are also still being investigated. While there is no evidence so far that it causes more severe disease, scientists do have some specific concerns.

1. It’s harder to differentiate

A marker that helped differentiate Omicron (BA.1) from other SARS-CoV-2 variants on PCR tests is the absence of the the S gene, known as “S gene target failure”. But this is not the case for BA.2.

The inability to detect this lineage in this way has led some to label it the “stealth sub-variant”.

But it doesn’t mean we can’t diagnose BA.2 with PCR tests. It just means when someone tests positive for SARS-CoV-2, it will take us a little longer to know which variant is responsible, through genome sequencing. This was the case with previous variants.

2. It may be more infectious

Perhaps most concerning is emerging evidence BA.2 may be more infectious than the original Omicron, BA.1.

A preliminary study from Denmark, where BA.2 has largely replaced BA.1, suggests BA.2 increases unvaccinated people’s susceptibility of infection by just over two times when compared to BA.1.

The researchers suggest fully vaccinated people are 2.5 times more susceptible to BA.2 than BA.1, and those who were booster vaccinated are nearly three times more susceptible.

The study examined more than 2,000 primary household cases of BA.2 to determine the number of cases that arose during a seven-day follow up period.

The researchers also estimated the secondary attack rate (basically, the probability infection occurs) to be 29 per cent for households infected with BA.1 versus 39 per cent for those infected with BA.2.

This Danish study is still a preprint, meaning it’s yet to be checked by independent scientists, so more research is needed to confirm if BA.2 is truly more infectious than BA.1.

We’re likely to see new variants We should expect new variants, sub-variants and lineages to continue to emerge. With such high levels of transmission, the virus has abundant opportunity to reproduce and for errors or mutations to continue to arise.

The way to address this, of course, is to try to slow transmission and reduce the susceptible pool of hosts in which the virus can freely replicate.

Strategies such as social distancing and mask-wearing, as well as increasing vaccination rates globally, will slow the emergence of new variants and lineages. 

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News Network
December 18,2024

The Israeli prime minister says the regime's troops will remain stationed at a so-called “buffer zone” inside the occupied Syrian Golan Heights, seized following the fall of President Bashar al-Assad, until another arrangement is found that will "ensure the usurping regime’s security."

Benjamin Netanyahu made the comments on Tuesday from the summit of Mount Hermon, known as Jabal al-Shaykh in Arabic, the highest peak in the area — inside Syria, about 10 kilometers (6 miles) from the border with the strategic Golan Heights.

He was joined by the Israeli minister for military affairs, Israel Katz, Chief of Staff Lieutenant General Herzi Halevi, head of the so-called internal security service Shin Bet, Ronen Bat, and Northern Command chief Major General Uri Gordin.

Netanyahu reiterated that Israel would remain in the area “until another arrangement can be found that guarantees Israel’s security.”

The prime minister said he had been on the same mountaintop 53 years ago as a soldier, but the summit’s importance to the Tel Aviv regime’s security has only increased given recent events.

It appeared to be the first time a sitting Israeli leader had set foot that far into Syrian territory.

For his part, Katz said Israeli forces would remain on the Syrian summit of Mount Hermon for “as long as necessary.”

He said, “We will stay here for as long as necessary,” asserting that deployment of Israeli troops to the strategically significant summit “strengthens security.”

“Mount Hermon's summit is Israel's eyes for identifying near and distant threats. From here, we can see Hezbollah positions in Lebanon to the right, and Damascus to the left,” Katz said.

Israeli military forces captured the UN-patrolled buffer zone in the Golan Heights hours after armed groups took control of the Syrian capital of Damascus on December 8.

Israel has been widely and vehemently condemned over termination of the 1974 ceasefire agreement with Syria, and exploiting the chaos in the Arab nation in the wake of Assad’s downfall to make a land grab.

The buffer zone in the Israeli-occupied Golan Heights was created by the United Nations after the 1973 Arab-Israeli War.  A UN force of about 1,100 troops had patrolled the area since then.

Stephane Dujarric, spokesman for UN Secretary General Antonio Guterres, said on Tuesday that the presence of Israeli soldiers, however long it lasts, violates the deal that established the buffer zone.

That agreement “needs to be respected, and occupation is occupation, whether it lasts a week, a month or a year, it remains occupation,” Dujarric pointed out.

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News Network
December 16,2024

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In a significant milestone, the Dakshina Kannada Zilla Panchayat Higher Primary School in Newpadpu, Harekala, has introduced a bilingual Kannada-English medium this academic year, a move spearheaded by Padma Shri awardee Harekala Hajabba. The school has so far received 13 admissions for its Class 1 bilingual program.

This initiative is part of a broader effort by the state government, which approved 38 schools across the district to launch bilingual mediums. Expressing his delight, Hajabba shared that he had been advocating for a bilingual school for years. "The bilingual medium will greatly benefit students in this region who otherwise rely on private schools. However, we currently face a shortage of classrooms. Construction of two additional classrooms is underway, and once completed, we expect higher admissions," he said.

The school had previously been permitted to introduce LKG and UKG classes in the last academic year. According to the school’s headmistress, Rajeshwari, while the pre-primary sections have seen good enrolment, the bilingual Class 1 faced challenges, securing only 13 students. She attributed this to the late notification of permission, which arrived a month after the academic year began, leading many children to enroll elsewhere.

Rajeshwari remains optimistic about the future. "We expect better admissions next academic year as awareness about bilingual education at this government school grows," she said, adding that the classroom shortage will soon be addressed.

Deputy Director of Public Instruction (DDPI) Venkatesha Subraya Patagara noted that bilingual schools across Dakshina Kannada have generally received a positive response, with some schools enrolling more than 100 students. The effort to offer bilingual education in government schools marks a step forward in providing affordable, quality education to underserved regions.

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News Network
December 12,2024

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New Delhi: The Union Cabinet on Thursday approved bills to implement 'One Nation, One Election', and the draft legislations are likely to be introduced in Parliament in the ongoing Winter session, sources said.

The decision was taken at a meeting of the Union Cabinet chaired by Prime Minister Narendra Modi.

The government is keen on holding wider consultations on bills which are likely to be referred to a parliamentary committee.

Sources said the government was also keen to consult the Speakers of various state legislative assemblies through the committee.

Moving ahead with its 'one nation, one election' plan, the government in September accepted the recommendations of the high-level committee for holding simultaneous polls for the Lok Sabha, state assemblies and local bodies in a phased manner.

Citing recommendations of the high-level committee, sources had said one of the proposed bills would seek to amend Article 82A by adding sub-clause (1) relating to the appointed date. It will also seek to insert sub-clause (2) to Article 82A relating to the end of terms of the Lok Sabha and state legislative assemblies together.

It also proposes to amend Article 83(2) and insert new sub-clauses (3) and (4) relating to the duration and dissolution of the Lok Sabha. It also has provisions related to the dissolution of the legislative assemblies and amending Article 327 to insert the term simultaneous elections.

This bill will not require ratification by at least 50 per cent of the states, the recommendation said.

However, any move to hold local body elections together with Lok Sabha and state assemblies will require ratification by at least 50 per cent of the state assemblies as it deals with matters relating to state affairs.

Another bill will be an ordinary one to amend provisions in three laws dealing with Union territories having legislative assemblies -- Puducherry, Delhi and Jammu and Kashmir -- to align the terms of these Houses with other legislative assemblies and the Lok Sabha as proposed in the first constitutional amendment bill.

The statutes it proposes to amend are the Government of National Capital Territory of Delhi Act-1991, the Government of Union Territories Act-1963 and the Jammu and Kashmir Reorganisation Act-2019.

The proposed bill will be an ordinary legislation not requiring a change in the Constitution and will also not need ratification by the states.

The high-level committee had proposed amendments to three Articles, insertion of 12 new sub-clauses in the existing articles and tweaking three laws related to Union Territories having legislative assemblies. The total number of amendments and new insertions stands at 18.

In its report submitted to the government in March, just before the general election was announced, the panel recommended implementing one nation, one election in two phases.

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