Here’s what we know about BA.2, the sister of Omicron

Agencies
February 3, 2022

Cases of the SARS-CoV-2 variant Omicron have escalated globally over the past two months, with many countries experiencing peaks higher than previous variants.

Now we’re seeing cases of a sub-variant of Omicron, known as BA.2, emerge in Australia and more than 50 countries.

Rather than a daughter of the Omicron variant BA.1 (or B.1.1.529), it’s more helpful to think of BA.2 as Omicron’s sister.

Remind me, what is a variant?

Viruses, and particularly RNA viruses such as SARS-CoV-2, make lots of mistakes when they reproduce. They can’t correct these mistakes, so they have a relatively high rate of errors, or mutations, and are constantly evolving.

When the genetic code of a virus changes as a result of these mutations, it’s referred to as a variant.

Omicron is a “highly divergent” variant, having accumulated more than 30 mutations in the spike protein. This has reduced the protection of antibodies from both prior infection and vaccination, and increased transmissibility.

When do health authorities worry about a new variant?

If changes in the genetic code are thought to have the potential to impact properties of the virus that make it more harmful, and there’s significant transmission in multiple countries, it will be deemed a “variant of interest”.

If a variant of interest is then shown to be more infectious, evade protection from vaccination or previous infection, and/or impact the performance of tests or treatments, it is labelled a “variant of concern”.

The World Health Organization (WHO) classified Omicron a variant of concern on November 26 because of its potential to cause higher reinfection rates, increased transmissibility and reduced vaccine protection.

What is the Omicron lineage?

A lineage, or sub-variant, is a genetically closely related group of virus variants derived from a common ancestor.

The Omicron variant comprises three sub-lineages: B.1.1.529 or BA.1, BA.2 and BA.3.

While the WHO has not given BA.2 a separate classification, the United Kingdom has labelled BA.2 a variant “under investigation”. So not yet a variant of interest or concern, based on WHO definitions, but one that is being watched closely.

This is not the first variant to have sub-lineages. Late last year, Delta “plus” or AY.4.2 was reported widely, then Omicron came along.

What’s different about BA.2?

While the first sequences of BA.2 were submitted from the Philippines – and we have now seen thousands of cases, including in the United States, the UK and some in Australia – its origin is still unknown.

The exact properties of BA.2 are also still being investigated. While there is no evidence so far that it causes more severe disease, scientists do have some specific concerns.

1. It’s harder to differentiate

A marker that helped differentiate Omicron (BA.1) from other SARS-CoV-2 variants on PCR tests is the absence of the the S gene, known as “S gene target failure”. But this is not the case for BA.2.

The inability to detect this lineage in this way has led some to label it the “stealth sub-variant”.

But it doesn’t mean we can’t diagnose BA.2 with PCR tests. It just means when someone tests positive for SARS-CoV-2, it will take us a little longer to know which variant is responsible, through genome sequencing. This was the case with previous variants.

2. It may be more infectious

Perhaps most concerning is emerging evidence BA.2 may be more infectious than the original Omicron, BA.1.

A preliminary study from Denmark, where BA.2 has largely replaced BA.1, suggests BA.2 increases unvaccinated people’s susceptibility of infection by just over two times when compared to BA.1.

The researchers suggest fully vaccinated people are 2.5 times more susceptible to BA.2 than BA.1, and those who were booster vaccinated are nearly three times more susceptible.

The study examined more than 2,000 primary household cases of BA.2 to determine the number of cases that arose during a seven-day follow up period.

The researchers also estimated the secondary attack rate (basically, the probability infection occurs) to be 29 per cent for households infected with BA.1 versus 39 per cent for those infected with BA.2.

This Danish study is still a preprint, meaning it’s yet to be checked by independent scientists, so more research is needed to confirm if BA.2 is truly more infectious than BA.1.

We’re likely to see new variants We should expect new variants, sub-variants and lineages to continue to emerge. With such high levels of transmission, the virus has abundant opportunity to reproduce and for errors or mutations to continue to arise.

The way to address this, of course, is to try to slow transmission and reduce the susceptible pool of hosts in which the virus can freely replicate.

Strategies such as social distancing and mask-wearing, as well as increasing vaccination rates globally, will slow the emergence of new variants and lineages. 

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News Network
April 24,2024

columbia.jpg

Pro-Gaza US protesters in New York's Columbia University say they will stay put despite the university's harassment and police crackdown.

The protesters said they refuse to concede to "cowardly threats and blatant intimidation" by university administration, asserting that they will continue to peacefully protest.

Columbia University threatened the students with the national guard after refusing to bargain in good faith.

The university announced a midnight deadline for talks regarding the removal of pro-Palestine encampments on the varsity campus, warning that their campsite will be forcefully cleared by police if no agreement is reached.

The university campus is being used as a campsite for hundreds of pro-Palestine protesters and other activists, who have gathered and set up numerous tents.

Pro-Palestinian protests at colleges have demanded that their universities divest from corporations doing business with Israel or profiting off the war in Gaza. At Columbia, protesters have also asked the university to end a dual-degree program with Tel Aviv University.

The deadline was announced by Columbia University President Minouche Shafik late Tuesday, as authorities across major American universities have launched their repression campaigns against the pro-Palestinian protests on campuses, amid rising anger over US's support for Israel. 

Shafik has issued a midnight deadline to protesters and organizers, warning that failure to comply will result in the forcible clearance of the camp by the New York Police Department (NYPD).

The university has engaged in discussions with student leaders behind the protests, which are part of a series of protests taking place at various colleges nationwide and resulting in multiple arrests.

The purpose of these talks is to address the encampment on the west lawn of Columbia's Morningside Heights campus.

American universities are grappling with the challenge of maintaining a delicate balance between the right to protest and freedom of speech, while also ensuring campus rules and safety, as tensions surrounding the ongoing war in Gaza continue to permeate across campuses.

Meanwhile, Shafik underscored the importance of free speech and the right to demonstrate, but highlighted significant safety issues, disruptions to campus activities, and a strained environment due to the encampment. She firmly stated that any form of intimidation, harassment, or discrimination would not be accepted.

The arrest of more than 100 protesters at Columbia University last week led to more campus demonstrations, at New York University, Yale, and the University of California, Berkeley.

Palestinian university professor Sami al-Arian said what is happening across US university campuses is unprecedented.

Al-Arian said, "I lived four decades in the US, 28 years of which were in academic settings. During my time, it was a very challenging struggle to present an anti-Zionist narrative."

"But the passion, courage, humanity, creativity, and determination displayed these days by students across US campuses make me proud. The Zionist grip on US society is weakening and waning."

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News Network
April 25,2024

EVM.jpg

Electronics Corporation of India Ltd and Bharat Electronics Ltd have refused to disclose the names and contact details of the manufacturers and suppliers of various components of EVMs and VVPATs under the RTI Act citing "commercial confidence", according to RTI responses from the PSUs to an activist.

Activist Venkatesh Nayak had filed two identical Right To Information applications with the ECIL and BEL, seeking the details of the manufacturers and suppliers of various components used in the assembling of the electronic voting machines (EVMs) and voter-verifiable paper audit trail (VVPATs).

The VVPAT is an independent vote verification system which enables electors to see whether their votes have been cast correctly.

The ECIL and the BEL, public sector undertakings under the Ministry of Defence, manufacture EVMs and VVPATs for the Election Commission.

Nayak also sought a copy of the purchase orders for the components from both PSUs.

"Information sought is in commercial confidence. Hence details cannot be provided under Section 8(1)(d) of the RTI Act," BEL said in its response.

A similar response was sent by ECIL which said the details requested are related to a product which is being manufactured by ECIL, and third party in nature.

"Disclosing of details will affect the Competitive position of ECIL. Hence, Exemption is claimed under section 8(1) (d) of RTI ACT, 2005," it said.

In response to the purchase order copies, ECIL's central public information officer said the information is "voluminous" which would disproportionately divert the resources of the Public Authority.

"Further, the information will give away the design details of EVM components. The same may pose a danger to the machines produced. Hence, the exemption is claimed U/s 7(9) and under section 8(1)(d) of RTI Act, 2005," ECIL said.

Section 8(1)(d) of the RTI Act exempts from disclosure the information, including commercial confidence, trade secrets or intellectual property, the disclosure of which would harm the competitive position of a third party, unless the competent authority is satisfied that larger public interest warrants the disclosure of such information.

Section 7(9) of the Act says the information shall ordinarily be provided in the form in which it is sought unless it would disproportionately divert the resources of the public authority or would be detrimental to the safety or preservation of the record in question.

"I don't know whose interests they are trying to protect against the right to know of close to a billion-strong electorate. ECIL said that disclosure of the purchase orders will reveal the design details of the components and this may pose a danger to the machines produced. ECIL did not upload even a signed copy of its reply on the RTI Online Portal," Nayak said.

He said it is reasonable to infer that the two companies are not manufacturing every single item of the EVM-VVPAT combo or else the two companies would have replied that they are manufacturing all these components internally without any outsourcing being involved.

"But the electorate is expected to take everything about the voting machines based on what the ECI is claiming in its manuals and FAQs," Nayak said.

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News Network
April 25,2024

Bengaluru: Karnataka State Natural Disaster Monitoring Centre (KSNDMC) has issued a series of animated shorts in Kannada advising people of appropriate measures to take during extreme temperatures to keep oneself safe.

 “Karnataka has not seen such extreme temperatures and heat waves in the recent past. So, we wanted to ensure a wider reach for safety measures, therefore we decided to issue them in a reader-friendly format,” said an official from KSNDMC.

Meteorological Centre Bengaluru, Indian Meteorological Department, had issued a five-day heat wave warning, lasting till April orange alert, for parts of Karnataka.

“In places like Bagalkote, Vijayapura, Kalaburgi, Yadgir, Raichur, Koppal, Ballari, Tumkur, Mandya, Gadag, Davangere and Chitradurga, the temperature is likely to touch 40 degrees Celsius tomorrow,” said C P Patil, director of the centre.

On April 25, these places recorded a maximum temperature of 39 degrees Celsius.

Orange alert would mean increased likelihood of heat illness symptoms in people who are exposed to sun for a prolonged period of time as well as those who do heavy manual work.

According to Patil, coastal Karnataka will also have very hot and humid weather conditions, making it very uncomfortable for people there.

“It’s best for children and old people to avoid exposure to heat in coastal areas too,” added Patil.

In places where heat wave is predicted, people are advised to avoid direct exposure to sunlight between 12 noon and 3pm.

“When they go out, it is best to use protective goggles, an umbrella or a hat. Also aerated drinks must be avoided since they cause dehydration. Best to drink water as much as possible, even if you don’t feel thirsty,” said M Rajavel, head of LACD, Meteorological Centre, Bengaluru.

People are also advised not to leave the children or pets inside parked vehicles.

The maximum and minimum temperatures of Bengaluru are very likely to be around 37 degree Celsius and 23 degree Celsius respectively for the next 48 hours, said Patil.

Hassan recorded the highest jump from its normal minimum temperature. It recorded 22.6 degrees Celsius, about 2.8 degrees more than usual.

According to IMD, on April 29 light rain is also very likely in isolated places over Bidar, Kalaburgi, Yadgir, Vijayapura, Chikkamagaluru, Hassan, Kodagu, Mysuru, Mandya and Chitradurga districts.

On April 30, light rain is predicted again for Bidar, Kalaburgi, Yadgir, Vijayapura, Raichur, Koppal, Ballari, Chikkamagaluru, Tumkur, Chikkaballapura, Bengaluru Rural, Bengaluru Urban and Kodagu districts.

Incidentally, KSNDMC has also issued a series of animated advisory for lightning safety.

“We also update temperature every 15 minutes in our X handle in coordination with IMD,” added the KSNDMC official.

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