New covid-19 variant 'Delta plus' identified; Should India be worried?

Agencies
June 14, 2021

The highly transmissible Delta variant of SARS-CoV-2 has mutated further to form the ‘Delta plus’ or ‘AY.1’ variant but there is no immediate cause for concern in India as its incidence in the country is still low, scientists said.

The new Delta plus variant has been formed due to a mutation in the Delta or B.1.617.2 variant, first identified in India and one of the drivers of the deadly second wave. Though there is no indication yet of the severity of the disease due to the new variant, Delta plus is resistant to the monoclonal antibody cocktail treatment for Covid-19 recently authorised in India.

“One of the emerging variants is B.1.617.2.1 also known as AY.1 characterized by the acquisition of K417N mutation,” Vinod Scaria, clinician and scientist at Delhi’s CSIR-Institute of Genomics and Integrative Biology (IGIB), tweeted on Sunday.  

The mutation, he said, is in the spike protein of SARS-COV-2, which helps the virus enter and infect the human cells.  

According to Public Health England, 63 genomes of Delta (B.1.617.2) with the new K417N mutation have been identified so far on the global science initiative GISAID.  

In its latest report on coronavirus variants, updated till last Friday, the health agency said Delta plus was present in six genomes from India as of June 7.  

“The variant frequency for K417N is not much in India at this point in time. The sequences are mostly from Europe, Asia and America,” Scaria wrote on Twitter.  

The earliest sequence of this genome was found in Europe in late March this year.  

Noting that the travel histories for the variant are not readily available to make assumptions, Scaria said an important point to consider regarding K417N is the “evidence suggesting resistance to monoclonal antibodies Casirivimab and Imdevimab”.

This cocktail recently received emergency-use authorization in the country from the Central Drugs Standard Control Organisation. Drug majors Roche India and Ciplas have priced the antibody cocktail at a steep Rs 59,750 per dose.  

Similar to antibodies which are proteins that the body naturally produces to defend itself against the disease, monoclonal antibodies are artificially created in a lab and tailor-made to fight the disease they treat.  

Casirivimab and Imdevimab are monoclonal antibodies that are specifically directed against the spike protein of SARS-CoV-2, and designed to block the virus' attachment and entry into human cells.  

Scaria also indicated the mutation may be associated with the ability to escape the immune response against the virus.

Allaying fears, immunologist Vineeta Bal noted that while there may be some setback in the use of commercial antibody cocktail due to the new variant, resistance to the therapy is not an indication of higher virulence or severity of a disease.  

“How transmissible this new variant is will be a crucial factor to determine its rapid spread or otherwise,” Bal, guest faculty at the Indian Institute of Science Education and Research, Pune, told PTI.  

She also noted that the quality and quantity of neutralising antibodies, responsible for defending cells from pathogens, generated in the individual infected with the new variant is unlikely to be affected because of the mutation.  

“Thus in individuals catching infection with the new variant, it may not be a matter worth worrying,” she added. 

Pulmonologist and medical researcher Anurag Agrawal concurred.  

“There is no cause of concern due to the new variant in India as of now,” Agrawal, the director of CSIR-IGIB, told PTI.

The scientist said the blood plasma from many fully vaccinated individuals will have to be tested against this variant to determine whether it shows any significant immune escape.  As the Delta variant continues to evolve and acquire new mutations, there is a lot of interest in understanding its evolution. He said SARS-CoV-2 has a nearly constant rate of acquiring genetic variants, and each variant has acquired additional variants in a stepwise fashion.

“Understanding this continued evolution is of great importance in mapping the evolutionary landscape of emerging variants. Largely the virus has tried to optimise for transmission and immune escape by step-wise acquisition of new mutations,” he added 

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News Network
May 8,2025

US President Donald Trump says he is willing to reach an agreement with Iran that allows Washington to “blow up” Tehran’s nuclear energy facilities.

“It’s that simple,” he said during an exchange with conservative radio host Hugh Hewitt, on Wednesday.

“I would much prefer a strong, verified deal where we actually blow them up…,” Trump said, referring to Iran’s nuclear facilities.

Deal’s outcome: Either ‘Nice aggression’ or ‘vicious aggression’

The 78-year-old former president added that there were only two possible outcomes, namely “blowing them up nicely or blow them up viciously.”

This is not the first time, Trump and other American officials have urged “total dismantlement” of Iran’s nuclear energy program. The US president had last made the insistence during comments on the NBC's "Meet the Press" program.

Observers said such statements underline the US administration's continued aggressive approach towards the Islamic Republic and its nuclear energy program.

The adversarial standing comes while Washington and Tehran have been engaging in indirect talks since March. The talks’ initiation marked drawn-out absence of such engagement between the two sides that had been caused by Washington’s illegal and unilateral withdrawal from a historic nuclear deal between Tehran and others in 2018.

Most recently, Trump’s regional envoy Steve Witkoff said, “The president wants to see this solved diplomatically if possible, so we’re doing everything we can to get it going."

Trump’s remarks, though, diagonally contradict Witkoff’s statement about the president’s alleged interest in a diplomatic solution.

Trump also said potential American aggression against Iran’s nuclear sites had to result in “de-nuking them.”

The US and its allies have for long been trying to accuse the Islamic Republic of pursuing “nuclear weapons,” despite the country’s repeated avowal not to either pursue, develop, or stockpile such weaponry as per moral and religious imperatives.

Tehran’s peaceful nuclear policy has been verified unexceptionally by the International Atomic Energy Agency (IAEA) which has never found any indication of such pursuit, as it has put the country's nuclear activities under the most extensive investigative processes compared to any other member of the United Nations nuclear agency.

The Western narrative, though, has been used extensively to try to justify escalating sanctions, military threats, and covert operations targeting Iran and its nuclear infrastructure.

Nevertheless, the Islamic Republic has invariably vowed to deal effectively with attempts on the part of the US, its allied states, or proxies at engaging in military adventurism against the country.

The assertion was last reiterated by Amir Saeid Iravani, Iran's permanent ambassador to the United Nations, who underscored on Monday that the country would unquestionably defend its sovereignty against any threat or use of force.

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News Network
May 8,2025

New Delhi: The government is briefing an all-party meeting on Thursday on the success of "Operation Sindoor" and its aftermath, as top government functionaries and opposition leaders met for a second time in a fortnight amid rising tensions between India and Pakistan following the Pahalgam terror attack on April 22.

Union ministers Rajnath Singh, Amit Shah, S Jaishankar, J P Nadda and Nirmala Sitharaman represented the government, while Rahul Gandhi and Mallikarjun Kharge from the Congress, Sandip Bandyopadhyay of the Trinamool Congress and DMK's T R Baalu were among the leading opposition figures in the meeting.

Other opposition leaders included Ram Gopal Yadav of the Samajwadi Party, Sanjay Singh of the AAP, Shiv Sena (UBT)'s Sanjay Raut, NCP (SP)'s Supriya Sule, BJD's Sasmit Patra and CPI(M)'s John Brittas.

JD(U) leader Sanjay Jha, Union minister and LJP (Ram Vilas) leader Chirag Paswan and AIMIM MP Asaduddin Owaisi were also part of the meeting.

Parliamentary Affairs Minister Kiren Rijiju said the government wanted to brief all parties on "Operation Sindoor".

In retaliation for the Pahalgam terror attack, Indian armed forces carried out missile strikes early Wednesday on nine terror targets in Pakistan and Pakistan-occupied Kashmir, including the Jaish-e-Mohammad stronghold of Bahawalpur and Lashkar-e-Taiba's base Muridke.

The military strikes were carried out under 'Operation Sindoor' two weeks after the massacre of 26 civilians in Jammu and Kashmir's Pahalgam.

The government had earlier called an all-party meeting on April 24 to brief leaders on the attack.

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News Network
May 10,2025

indianarmy.jpg

In a significant escalation of hostilities, the Indian Army has reported that Pakistan targeted critical civilian infrastructure, including hospitals and school premises, in Srinagar, Awantipur, and Udhampur. This incident marks a severe breach of international norms, with Pakistan's actions drawing widespread condemnation.

Details of the Attacks

Wing Commander Vyomika Singh, during a press briefing, said that Pakistan's military launched attacks on Indian Army hospitals and educational institutions in these regions. The targeted facilities are located within or near military airbases, raising concerns about the deliberate targeting of civilian infrastructure. The attacks have resulted in significant damage to these establishments, though specific casualty figures are yet to be confirmed.

Indian Army's Response

The Indian Army has termed these actions as "unacceptable" and a direct violation of international humanitarian law. In retaliation, India has initiated "Operation Sindoor," a series of strikes targeting Pakistani military bases and terrorist infrastructure. The operation aims to dismantle terror networks operating from across the border and to send a strong message against such provocations.

The international community has expressed grave concern over the escalation. The United Nations has called for maximum restraint from both nations to prevent further deterioration of the situation. Countries like the United States, Russia, and China have urged India and Pakistan to engage in dialogue and de-escalate tensions.

As of now, the situation remains tense. Both nations have mobilized additional troops along the Line of Control (LoC), and airspace in the affected regions has been restricted. Civilians in the targeted areas have been advised to stay indoors, and emergency services are on high alert to respond to any further incidents.

This development marks a significant turning point in the ongoing India-Pakistan tensions, with the targeting of civilian infrastructure raising the stakes of the conflict. The coming days will be crucial in determining the trajectory of relations between the two nuclear-armed neighbors.

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