New covid-19 variant 'Delta plus' identified; Should India be worried?

Agencies
June 14, 2021

The highly transmissible Delta variant of SARS-CoV-2 has mutated further to form the ‘Delta plus’ or ‘AY.1’ variant but there is no immediate cause for concern in India as its incidence in the country is still low, scientists said.

The new Delta plus variant has been formed due to a mutation in the Delta or B.1.617.2 variant, first identified in India and one of the drivers of the deadly second wave. Though there is no indication yet of the severity of the disease due to the new variant, Delta plus is resistant to the monoclonal antibody cocktail treatment for Covid-19 recently authorised in India.

“One of the emerging variants is B.1.617.2.1 also known as AY.1 characterized by the acquisition of K417N mutation,” Vinod Scaria, clinician and scientist at Delhi’s CSIR-Institute of Genomics and Integrative Biology (IGIB), tweeted on Sunday.  

The mutation, he said, is in the spike protein of SARS-COV-2, which helps the virus enter and infect the human cells.  

According to Public Health England, 63 genomes of Delta (B.1.617.2) with the new K417N mutation have been identified so far on the global science initiative GISAID.  

In its latest report on coronavirus variants, updated till last Friday, the health agency said Delta plus was present in six genomes from India as of June 7.  

“The variant frequency for K417N is not much in India at this point in time. The sequences are mostly from Europe, Asia and America,” Scaria wrote on Twitter.  

The earliest sequence of this genome was found in Europe in late March this year.  

Noting that the travel histories for the variant are not readily available to make assumptions, Scaria said an important point to consider regarding K417N is the “evidence suggesting resistance to monoclonal antibodies Casirivimab and Imdevimab”.

This cocktail recently received emergency-use authorization in the country from the Central Drugs Standard Control Organisation. Drug majors Roche India and Ciplas have priced the antibody cocktail at a steep Rs 59,750 per dose.  

Similar to antibodies which are proteins that the body naturally produces to defend itself against the disease, monoclonal antibodies are artificially created in a lab and tailor-made to fight the disease they treat.  

Casirivimab and Imdevimab are monoclonal antibodies that are specifically directed against the spike protein of SARS-CoV-2, and designed to block the virus' attachment and entry into human cells.  

Scaria also indicated the mutation may be associated with the ability to escape the immune response against the virus.

Allaying fears, immunologist Vineeta Bal noted that while there may be some setback in the use of commercial antibody cocktail due to the new variant, resistance to the therapy is not an indication of higher virulence or severity of a disease.  

“How transmissible this new variant is will be a crucial factor to determine its rapid spread or otherwise,” Bal, guest faculty at the Indian Institute of Science Education and Research, Pune, told PTI.  

She also noted that the quality and quantity of neutralising antibodies, responsible for defending cells from pathogens, generated in the individual infected with the new variant is unlikely to be affected because of the mutation.  

“Thus in individuals catching infection with the new variant, it may not be a matter worth worrying,” she added. 

Pulmonologist and medical researcher Anurag Agrawal concurred.  

“There is no cause of concern due to the new variant in India as of now,” Agrawal, the director of CSIR-IGIB, told PTI.

The scientist said the blood plasma from many fully vaccinated individuals will have to be tested against this variant to determine whether it shows any significant immune escape.  As the Delta variant continues to evolve and acquire new mutations, there is a lot of interest in understanding its evolution. He said SARS-CoV-2 has a nearly constant rate of acquiring genetic variants, and each variant has acquired additional variants in a stepwise fashion.

“Understanding this continued evolution is of great importance in mapping the evolutionary landscape of emerging variants. Largely the virus has tried to optimise for transmission and immune escape by step-wise acquisition of new mutations,” he added 

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News Network
November 7,2024

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Mangaluru, Nov 7: In the quiet village of Tippunagar, Loretto Padavu, a heartbreaking accident claimed the life of three-year-old Aashika on Wednesday, leaving a family and community shattered.

Aashika, the beloved daughter of Unais from Pattanabailu near Farangipet, was simply enjoying a carefree moment, playing outside her grandmother’s house. It was then that an unimaginable tragedy struck: a parked goods tempo, owned by her uncle, unexpectedly rolled backward, trapping the innocent child beneath its wheels.

Despite her family’s desperate rush to get her to the hospital, little Aashika’s injuries proved too severe, and she was declared dead upon arrival. Her passing has cast a deep shadow over the close-knit community, who grieve alongside her family for the life taken too soon.

The Bantwal traffic police have registered a case and are investigating the incident, while the community mourns the loss of a precious young soul who had only just begun to experience life’s wonder.
 

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News Network
November 15,2024

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Iran’s Islamic Revolution Guards Corps (IRGC) has killed or captured 69 terrorists linked to the Israeli spy agency Mossad during a major counterterrorism drill in the country's southeast, its spokesman says.  

General Ahmad Shafaei, the spokesman for the “Martyrs of Security” drill, said Friday that a total of 23 terrorists have been killed and another 46 arrested in various clean-up operations ever since the IRGC Ground Force launched it in the Sistan and Baluchestan province on November 1.

Seven terrorists have also turned themselves in during the period.

“The undeniable fact about terrorists is that they rely on arrogant powers, particularly the intelligence service of the wicked and vicious Zionist regime," Shafaei said.

“Unfortunately, weapons and munitions at terrorists’ disposal are among the most sophisticated ones in the world. This accounts for their heavy dependence.” 

The official stated that several members of the disbanded terror teams were non-Iranian nationals, who had been hired by foreign intelligence agencies to carry out acts of sabotage and terror inside Iran.

In a most recent operation, six terrorists were arrested and four others were eliminated, three of whom were non-Iranians, he added. 

On October 26, ten members of Iran's law enforcement forces were killed in a terrorist attack in the Gohar Kuh district of Taftan in the Sistan and Baluchestan province.

The so-called Jaish al-Adl terrorist group claimed responsibility for the assault, which was one of the deadliest in the province in recent months.

The group has carried out numerous terrorist attacks in Iran, primarily in Sistan and Baluchestan.

Its tactics include the abduction of border guards as well as targeting civilians and police stations within the province to incite chaos and disorder.

In January, Iran launched a military operation during which the headquarters of the Pakistan-based terrorist group was targeted in missile strikes, destroying its infrastructure.

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News Network
November 10,2024

Bengaluru: The Karnataka government has warned that disciplinary action will be taken against those officials who change the land mutation records and serve eviction notices to farmers under the Waqf Act.

In a letter, the Revenue Department Principal Secretary Rajender Kumar Kataria reminded all regional commissioners and deputy commissioners in the districts that Chief Minister Siddaramaiah recently had a meeting following complaints about certain land properties being made in favour of the Karnataka Board of Waqfs.

In the meeting it was decided that all the directions issued previously by any government office or authority to change the mutation records has been withdrawn, the letter said.

It added that all the notices served in the past have also been withdrawn and no action should be taken against the farmers who are cultivating on the said land.

On the directions of the chief minister, the previous letters and the latest reminders served on November 7 to the farmers and land owners have been withdraw, the letter said.

"The officials who served reminder-2 despite the chief minister's direction will face appropriate disciplinary action," Kataria said in his letter.

He said he has been instructed to strictly implement the chief minister's direction.

The fresh direction was issued in poll-bound Karnataka, where bypolls to three crucial assembly segments are due on November 13.

Some farmers in Honwad village in Vijayapura in north Karnataka had alleged last month that they were served eviction notices as the Waqf Board claimed rights over it.

Subsequently, complaints started in pouring in from some other parts of the state.

BJP leader Tejasvi Surya on October 25 alleged that Karnataka Waqf Minister B Z Zameer Ahmed Khan directed the deputy commissioners and revenue officials to register lands in favour of the Waqf Board within 15 days, which resulted in confusion.

On Surya's request, the Chairman of the Joint Committee of Parliament on the Waqf (Amendment) Bill, Jagdambika Pal visited Karnataka on November 7 and met farmers in Hubballi, Vijayapura and Belagavi districts who had alleged that their lands were marked as Waqf properties.

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