Serum Institute pauses covid 19 vaccine trials in India on DGCI instructions

Agencies
September 10, 2020

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New Delhi, Sept 10: The Serum Institute of India (SII), which was conducting the India trials for the coronavirus vaccine being developed by Oxford University, on Thursday paused the clinical trials of the vaccine in India.

In a statement, the Serum Institute of India said: "We are reviewing the situation and pausing India trials till AstraZeneca restarts the trials. We are following DCGI's instructions and will not be able to comment further on trials."

The declaration by the Pune-based vaccine manufacturer came a day after the Drug Control General of India (DCGI), V.G. Somani, issued a show-cause notice to them asking for an explanation as to why the institute decided to go ahead with the clinical trial of Covid-19 vaccine candidate while doubts about patient safety are yet unclear.

The notice was issued in the wake of an advert incident where one of the participants in the UK reported a suspected severe adverse reaction when administered a booster dose of Covishield, a vaccine candidate developed jointly by pharma giant AstraZeneca and University of Oxford, on Tuesday.

"Whereas, Serum Institute of India Pvt Ltd, Pune, till now has not informed the Central licensing authority regarding pausing the clinical trial carried out by AstraZeneca in other countries and also not submitted casualty analysis of the reported serious adverse event with the investigational vaccine for the continuation of phase 2 and 3 clinical trials of the subject vaccine in the country in light of the safety concerns," the notice by DGCI read.

The DGCI further asked the institute why the authority does not suspend the permission given to the SII for the clinical trials of Covishield.

"In view of the above, I, Dr V G Somani, Drugs Controller General of India and Central Licensing Authority hereby give you an opportunity to show cause as provided under rule 30 of the New Drugs and Clinical Trials Rules, 2019, why the permission granted to you August 2 shall not be suspended till patient safety is established," the notice further said.

SII is the partner of the University of Oxford's Jenner Institute's to conduct the vaccine trials. SII is currently progressing the second and third phase study of the vaccine candidate at 17 trial sites across India.

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News Network
April 11,2025

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Bengaluru, Apr 11: In a significant development, the Karnataka Cabinet on Friday formally accepted the controversial Socio-Economic and Educational Survey, popularly known as the caste census, nearly a decade after it was conducted. The report will be taken up for detailed discussion in a special Cabinet meeting on April 17.

The survey was originally carried out in 2015 by the Karnataka State Commission for Backward Classes under the chairmanship of H. Kantharaj, and finalised in February 2024 by his successor, K. Jayaprakash Hegde. The long-awaited report—comprising 50 volumes of detailed caste- and community-related data—was placed before the Cabinet in a sealed cover, which was opened during Friday’s meeting.

Backward Classes Welfare Minister Shivaraj Tangadagi, while briefing the media, said the report would now be distributed to all Cabinet ministers so they could examine its findings ahead of the April 17 meeting. Though the government did not disclose the contents of the report, it sought to validate the survey’s legitimacy by presenting statistical data.

“As per the 2011 Census, Karnataka’s population was 6.11 crore. By 2015, when the survey was conducted, it had grown to an estimated 6.35 crore. The survey covered 5.98 crore people—a coverage of 94.17 percent,” Tangadagi said.
He added that only 37 lakh people, or 5.83 percent, were left out of the enumeration process.

Highlighting the scale of the operation, the minister said 1.6 lakh government officials participated in the survey. An expert committee was constituted, which developed 54 criteria to guide the data collection. The state government also engaged Bharat Electronics Limited (BEL) to manage the survey data under a ₹43 crore agreement, with the total expenditure reaching ₹165 crore.

Law and Parliamentary Affairs Minister H. K. Patil announced that a special Cabinet session will be held on April 17 to deliberate on the report's contents. When asked about concerns over the completeness of the data, Patil responded, “Even in the national Census, some people are left out. A 94 percent coverage is a very significant achievement.”

The caste census remains a politically sensitive issue in Karnataka. Dominant communities such as the Lingayats and Vokkaligas have questioned the methodology of the 2015 survey, alleging undercounting. In contrast, Other Backward Classes (OBCs) and SC/ST groups have welcomed the report, arguing that it sheds light on social realities long ignored.

The Congress party had pledged to act on the caste census in its manifestos for the 2023 Karnataka Assembly elections and the 2024 Lok Sabha polls. National party leader Rahul Gandhi has also been advocating for a nationwide caste census.

The Cabinet’s acceptance of the report comes just days after Chief Minister Siddaramaiah’s meeting with Rahul Gandhi in New Delhi, and the Congress Working Committee’s session in Ahmedabad.

Six Ministers Skip Cabinet Meeting

At least six ministers were notably absent from Friday’s Cabinet meeting. These included:

    S. S. Mallikarjun and Laxmi Hebbalkar (both Lingayats)

    M. C. Sudhakar and K. Venkatesh (both Vokkaligas)

    R. B. Timmapur (SC)

    Madhu Bangarappa (Idiga community)

However, Minister Patil clarified that despite their absence, all ministers have endorsed the Cabinet’s collective decision, regardless of caste or community affiliations.

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News Network
April 7,2025

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Rafah, a city along the border of the Gaza Strip and Egypt, has entirely been “wiped off the map” by Israel’s brutal campaign of genocide and ethnic cleansing, says the Gaza government media office.

The media office said Sunday in a statement on X that the southern city of Gaza has entirely been demolished to make way for Israel to turn it into a “closed military operations zone."

The statement said Israel’s military forces have been carrying out “horrific massacres against defenseless civilians” in Rafah, creating a “full-fledged humanitarian disaster.”

According to the officials, Israeli forces have destroyed over 90% of homes—more than 20,000 buildings in Rafah.

All of the historical buildings, archaeological sites, museums, modern homes, the civilian infrastructure, the shops, cafes, restaurants, hospitals, schools, and universities have been demolished.

The officials said the regime's forces have also demolished 22 of 24 water wells, including a large water treatment plant and facility that was built 25 years ago by the Canadian government.

“Tens of thousands of families” are now without safe drinking water, and over 85% of the sewage system has been destroyed, raising fears of disease outbreaks, said the statement.

At least 12 medical centers are out of service, including Abu Yousef al-Najjar Hospital, which was reportedly blown up by an explosive robot.

Rafah is “uninhabitable,” now, the media office said.

The Israeli military’s goal, it said, is to “empty the land of its people and alter its geographic and demographic features.”

Rafah, a city that was built over 3,300 years ago, had a population of 171,889. As recently as February, 1.4 million Palestinians took shelter there as a result of Israel’s forced displacement of the population in northern parts of the besieged enclave.

The city, which was once designated as a "safe zone" by Israel's military, has now been reduced to rubble. The regime's military has now seized the ruins of Rafah and ordered every survivor out, to expand its "security buffer zone" along Gaza's borders.

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Avantika Bhat | coastaldigest.com
April 8,2025

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Mangaluru: The academic excellence of Dakshina Kannada continues to shine as the district secured a commendable 93.57% pass percentage in the II PU examinations, placing it second among all districts in Karnataka. Although it stood first last year with 97.37%, the district has maintained a consistent record of high performance.

Over the past years, Dakshina Kannada's performance has been as follows: 95.33% in 2022-23, 88.02% in 2021-22 (a year in which all students were declared pass due to the COVID-19 pandemic), 90.91% in 2018-19, 91.41% in 2017-18, 89.92% in 2016-17, 90.48% in 2015-16, 93.09% in 2014-15, 86.04% in 2013-14, and 85.88% in 2012-13.

Behind the Performance

In-charge Deputy Director of the PU Department, Sridhar H G, attributed the results to collective efforts.

“The department constituted taluk-level Shaikshanika Samithis, which analyzed results college-wise and helped identify areas needing improvement. Remedial classes were held for weaker students. Both government and private PU colleges worked hard, aiming for better outcomes. The district has also produced state toppers in both science and commerce streams,” he said.

Science Stream Brilliance from DK

Among the brightest stars is Bindu Navale from Alva’s PU College, who topped the Science stream with 598 marks, sharing the top spot with two others. A dedicated and sincere student, Bindu said she remained calm and consistent throughout the academic year. Her teachers praised her meticulous approach and in-depth understanding of core subjects. She now plans to appear for national-level entrance exams to pursue a career in the medical field.

Commerce Achievers Who Made DK Proud

In the Commerce stream, Pranay Balasaheb Alagouda and Vaishnavi Prasad Bhat, both from Alva’s PU College, secured 597 marks, earning their place among the state toppers. Pranay, who hails from Vijayapura, expressed deep gratitude for the academic environment at his college. He plans to pursue BCom with aspirations of cracking competitive exams. Vaishnavi, known for her consistent performance and disciplined study habits, aspires to explore the field of finance and management in the future.

Top Performers Speak

Shreevidya, a student of Government PU College, Kaniyoor, scored 595 in the Science stream. She said she had expected 598 marks and plans to apply for revaluation.

“I used to study three to four hours daily. Our lecturers supported us with study materials, which really helped. I aspire to clear the UPSC exam and will pursue BSc followed by MSc in Mathematics. I also write poems,” she said.

She is the daughter of Narayana A K and Shailashree.

Shreya S, a student of Expert PU College who hails from Hassan, scored 597 marks in Science. She plans to appear for NEET to pursue a career in medical sciences.

Her parents, Suresh and Savitha, are doctors.

P Yuktha Sree, a student of Vivekananda PU College, secured 593 marks in the Arts stream and expressed her delight at being one of the state toppers.

Hailing from Bengaluru, she said, “I was attentive in class and studied intensively during the final month. I plan to become an IAS officer and will pursue graduation along with UPSC coaching.”

Her principal, Mahesh, noted that Yuktha was diligent and often clarified her doubts with teachers.

Pramukh Tulupule, from Excellent PU College, Moodbidri, scored 596 in Science.

“There was no pressure. I studied regularly, and mock tests conducted by our teachers helped a lot. I aim to become an engineer,” he shared.

Anoop Shawn Gomes, also from Excellent PU College, Moodbidri, secured 596 marks in the Commerce stream.

Originally from Balehonnur in Chikkamagaluru, he said, “The environment in the college and hostel was supportive. I plan to pursue BCom along with Chartered Accountancy.”

Other Toppers

Arts Stream:

Prakruthi N, Alva’s PU College – 591

G Lavanya, St Aloysius PU College – 590

Niriksha Ria Noronha, St Agnes College – 590

Thafhima Fathima, St Aloysius PU College – 590

Banavath Mayukha, Alva’s PU College – 589

Commerce Stream:

Pranay Balasaheb Alagouda, Alva’s PU College – 597

Vaishnavi Prasad Bhat, Alva’s PU College – 597

Anoop Shawn Gomes, Excellent PU College, Moodbidri – 596

Hanshitha Shetty, St Aloysius PU College – 595

N Bindu Bhat, Canara PU College – 595

Priyamvrath Bhat, Vijaya PU College, Mulki – 595

Richa Ganesh Dalvi, Shakthi PU College – 595

Sannidhi Mangesh Shanbagh, Alva’s PU College – 595

Sharel Lavita Rodrigues, Alva’s PU College – 595

Vismaya Bhat, Alva’s PU College – 595

Adithi K, Excellent PU College – 594

Chaitanya N, Vivekananda PU College – 594

K S Siri Gowri, Vikas PU College – 594

Minnal Binu, Govinda Dasa PU College – 594

Pradyumna R Urala, St Aloysius PU College – 594

Shreyas M, Mangalore Independent PU College – 594

Vaishnavi Shetty, Alva’s PU College – 594

Science Stream:

Bindu Navale, Alva’s PU College – 598

Raja Yadu Vamshi Yadav, Alva’s PU College – 598

Vijet G Gowda, Alva’s PU College – 598

Akshay M Hegde, Alva’s PU College – 597

Preksha M S, Alva’s PU College – 597

Padmavati Malleshappa Badagi, Alva’s PU College – 596

Shadjay A P, Expert PU College – 596

Abhiraam Bhat, Satya Sai Lokaseva PU College – 595

Chinmanyi R, Expert PU College – 595

Darshan Shetty, Alva’s PU College – 595

Dhanyatha Gowda, Expert PU College – 595

Shri Vatsa, Satya Sai Loka Seva College – 595

Tushara B S, SDM College – 595

Rohan H Shenoy, Expert PU College – 595

Vachana Bagodi, Expert PU College – 595

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