India will have 'approved' vaccine by 2021 Q1: Bernstein Research

News Network
August 28, 2020

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New York, Aug 28: India is on course to have an "approved" vaccine within the first quarter of the calendar year 2021 and Pune based Serum Institute of India (SII), the world's largest vaccine manufacturer by volume, is well placed to deliver the first vaccine, according to a report out Thursday from Bernstein Research, a top Wall Street research and brokerage firm.

"Globally, there are four candidates that are close to approval by the end of the CY2020 or early 2021. Through partnerships India has access to two of those - AZ/Oxford's viral vector vaccine and Novavax's protein subunit vaccine with AZ/Oxford's vaccine ahead by a quarter," says the Bernstein report, which news agency has reviewed.

"With their existing capabilities and capacities, SII is best positioned to commercialize one or both of the partnered vaccine candidates depending on approval timing, capacities and pricing."

Data from Phase 1 and Phase trials look promising for both these candidates "in terms of safety and the vaccines' ability to elicit an immune response". The way things look now, the report indicates that both vaccine candidates "will require two doses to be administered 21/28 days apart".

The report strikes an upbeat tone on India's "global capacity equation" and does not foresee "manufacturing scale-up challenges".

Serum Institute of India, the report says, could supply 600 million doses in 2021 and 1 billion doses in 2022, out of which 400 to 500 million "should be available in India in 2021" in the context of the company's commitments to Gavi The Vaccine Alliance and lower and middle-income markets.

The report estimates that vaccine volumes will be split 55:45 between the government and the private market.

"We believe the government channel will have first access to the capacities but also believe there will be a sizable private market. In terms of funding, manpower and delivery infrastructure the Government will struggle to shoulder the burden on its own and we expect the private market to step in and supplement."

SII has announced that Gavi will procure vaccines at $3 per dose. The Bernstein report uses that as a benchmark to estimate procurement price to be around $3 a dose for the government and end consumer price of about $6 per dose.

Apart from SII, the report lists at least three other Indian pharma companies - Zydus, Bharat Biotech and Biological E - which are working on their own vaccine candidates and are currently in Phase 1 and 2.

Between SII, Bharat Biotech, Biological E, and some smaller players, India produces around 2.3 billion doses of various vaccines every year.

SII alone is the globally largest manufacturer of vaccines with 1.5 billion doses capacity. Every two out of three children globally get a shot manufactured by SII.

In early August, SII entered into a partnership with Gavi, The Vaccine Alliance and the Bill and Melinda Gates Foundation, to accelerate the manufacture and delivery of up to 100 million doses of COVID-19 vaccines for India and low- and middle-income countries (LMICs).

The collaboration pumps upfront capital to SII to help them increase manufacturing capacity now so that, once a vaccine, or vaccines, gains regulatory approval and WHO prequalification, doses can be produced at scale for distribution to India and lower and middle-income nations as quickly as the first half of 2021.

The overall vaccine market in India is estimated at "$6 billion spread over FY 21-22", according to Bernstein.

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News Network
November 5,2024

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Washington: The race between Democratic leader Kamala Harris and her Republican rival Donald Trump for the White House has been truly unprecedented as it saw drama, tragedy, political comebacks, fierce rhetoric and a historically razor-tight contest.

As the fight reaches its crescendo with the big election day just a few hours away, many political observers billed the unpredictable race for the 47th President of the US as the most consequential one in decades while appearing to project a grim picture for the country’s future under a Trump presidency.

In her final days of campaign, Vice President Harris focused on a message of hope, unity, optimism and women rights whereas Trump remained fiercely combative in targeting his Democratic rival and even suggested that he may not accept the election outcome in case of a defeat.

Overall, it has been a roller-coaster ride for both 60-year-old Harris and 78-year-old Trump.

Trump received his party’s nomination in March and formally at the Republican National Convention (RNC) in July — in a historic comeback after remaining in political wilderness for months following several court cases.

In effect, he became the first former president to get the nomination for the top office on the planet after being convicted of a felony.

“Trump has made one of the biggest political comebacks since Richard Nixon’s in terms of the political struggles that he has had in the last four years,” Communication Strategist Anang Mittal said.

Just days ahead of the RNC, Trump was shot at during a rally in Pennsylvania. He suffered an upper ear injury. Minutes later, a bleeding Trump raised his fist in defiance, images that drew a lot of emotional support from his die-hard supporters.

For Harris too, it has been a dramatic ride after Biden ended his re-election campaign in July, nearly weeks after he came under severe scrutiny following his incoherent performance at a televised debate with Trump.

While dropping out from the race, Biden, 81, endorsed Harris to succeed him as the Democratic candidate.

Finally in August, the Democratic National Convention formally nominated Harris as the party’s candidate for the presidential election.

The presidential election will be a chance to “move past the bitterness, cynicism and divisive battles of the past”, she said in a powerful speech at the Convention.

If Harris wins, she will become the first woman, first Black woman and first person of South Asian descent to become the US President.

In the overall campaign, Harris has been projecting the election as the one to protect the country’s fundamental freedoms, safeguard constitutional values and ensure women’s rights.

On his part, Trump has maintained his signature aggressive rhetoric and promising to rebuild the economy and rid the US from illegal immigrants.

However, there has been strong criticism of the Republican leader’s roadmap to repair the economy.

"Donald Trump is offering a vision of crony rentier capitalism that has enticed many captains of industry and finance,” said Joseph E Stiglitz, a Nobel laureate economist, in a column in Project Syndicate.

"In catering to their wishes for more tax cuts and less regulation, he would make most Americans’ lives poorer, harder, and shorter,” he said.

With election day just a few hours away, there is no clarity on who has a better chance of winning the race.

"The elections are very close. They (the outcome) may change on the basis of a few thousands votes here or there. I think the big issue will be voter turnout tomorrow. That will determine the outcome in certain swing states,” said Executive Director of the US chapter of Observer Research Foundation Dhruva Jaishankar.

Kapil Sharma, a non-resident senior fellow at Atlantic Council’s Middle East Programmes, also echoed similar views.

“This election is probably one of the closest elections that I can remember. I have been working in Washington for over 30 years and I don’t recall an election being this tight,” he said.

More than 78 million Americans have already cast their votes as of Sunday, according to the University of Florida’s Election Lab that tracks early and mail-in voting across the US.

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News Network
November 7,2024

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In a significant gesture towards a smooth transition, President Joe Biden invited President-elect Donald Trump to the White House to discuss the transfer of power, following a pledge from Vice President Kamala Harris to uphold a peaceful handover.

Vice President Harris, in a heartfelt address last night, publicly acknowledged Trump’s victory and assured her full commitment to a respectful and orderly shift in governance. "Our allegiance is not to any individual but to the Constitution itself," Harris emphasized, highlighting the need for national unity and respect for democratic processes.

Reports from The Washington Post reveal that Trump’s team is already hard at work on transition plans, actively considering candidates for key Cabinet positions. For Treasury Secretary, billionaire investor John Paulson and economic strategist Scott Bessent are in the running, while Senator Marco Rubio and former acting Director of National Intelligence Richard Grenell are top contenders for Secretary of State.

Additionally, the Trump camp is eyeing influential figures for strategic roles. North Dakota Governor Doug Burgum and former primary rival Vivek Ramaswamy are rumored to be cabinet-bound, with Senator Tom Cotton potentially taking on the role of Defense Secretary. The highest priority, however, is securing a Chief of Staff, with Trump advisor Susie Wiles and Brooke Rollins among the frontrunners for this critical post.

Trump's campaign has reportedly conducted a rigorous vetting process, aimed at bringing loyalists into his administration to ensure alignment with his goals. Campaign spokesperson Karoline Leavitt confirmed that personnel selections would be announced soon, while Trump spokesperson Steven Cheung confirmed that White House transition talks are imminent.

Adding to the intrigue, there are whispers that Robert F. Kennedy Jr. might take on a prominent role in restructuring health and food safety agencies. Known for his controversial views on vaccines, Kennedy’s potential appointment is already sparking debates across the political spectrum.

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News Network
November 4,2024

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Shah Rukh Khan, the Bollywood superstar once known for being a chain smoker, has revealed that he has finally kicked the habit. The revelation came during an event organized by his fan clubs in Bandra to celebrate his 59th birthday on Saturday. 

In a video shared by fans on X, Shah Rukh mentioned, "There’s a good thing – I’m not smoking anymore, guys. I thought I wouldn’t feel so breathless after quitting, but I still do. Inshallah, that will also improve."

The actor has faced criticism for his smoking in the past, most notably in 2012 when he was seen smoking during an IPL match between his team, Kolkata Knight Riders, and Rajasthan Royals. Shah Rukh was fined a modest Rs 100 after pleading guilty in court in Jaipur for smoking in public.

During the same event, Shah Rukh held an Ask SRK session where fans asked questions. One fan inquired about what he has learned from his children. In his signature witty style, Shah Rukh recounted his birthday morning with charming anecdotes: "I woke up late after a dinner last night, spent time with my little one whose iPad wasn’t working, then my daughter had issues with her outfits... and then my elder son." The actor’s relatable details entertained the crowd, as always.

Shah Rukh went on to say, "I learn a lot from my family. The more children you have, the more patient you become! That’s what I carry with me to work – patience, love, and care. Whether at home, on set, or in the office, I’m there to fix things for everyone. Patience is the biggest lesson my family has taught me."

Shah Rukh Khan’s career continues to soar after an impressive comeback, with blockbuster hits like Pathaan and Jawan. His recent film Dunki received a more mixed response from the audience.

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