New covid-19 variant 'Delta plus' identified; Should India be worried?

Agencies
June 14, 2021

The highly transmissible Delta variant of SARS-CoV-2 has mutated further to form the ‘Delta plus’ or ‘AY.1’ variant but there is no immediate cause for concern in India as its incidence in the country is still low, scientists said.

The new Delta plus variant has been formed due to a mutation in the Delta or B.1.617.2 variant, first identified in India and one of the drivers of the deadly second wave. Though there is no indication yet of the severity of the disease due to the new variant, Delta plus is resistant to the monoclonal antibody cocktail treatment for Covid-19 recently authorised in India.

“One of the emerging variants is B.1.617.2.1 also known as AY.1 characterized by the acquisition of K417N mutation,” Vinod Scaria, clinician and scientist at Delhi’s CSIR-Institute of Genomics and Integrative Biology (IGIB), tweeted on Sunday.  

The mutation, he said, is in the spike protein of SARS-COV-2, which helps the virus enter and infect the human cells.  

According to Public Health England, 63 genomes of Delta (B.1.617.2) with the new K417N mutation have been identified so far on the global science initiative GISAID.  

In its latest report on coronavirus variants, updated till last Friday, the health agency said Delta plus was present in six genomes from India as of June 7.  

“The variant frequency for K417N is not much in India at this point in time. The sequences are mostly from Europe, Asia and America,” Scaria wrote on Twitter.  

The earliest sequence of this genome was found in Europe in late March this year.  

Noting that the travel histories for the variant are not readily available to make assumptions, Scaria said an important point to consider regarding K417N is the “evidence suggesting resistance to monoclonal antibodies Casirivimab and Imdevimab”.

This cocktail recently received emergency-use authorization in the country from the Central Drugs Standard Control Organisation. Drug majors Roche India and Ciplas have priced the antibody cocktail at a steep Rs 59,750 per dose.  

Similar to antibodies which are proteins that the body naturally produces to defend itself against the disease, monoclonal antibodies are artificially created in a lab and tailor-made to fight the disease they treat.  

Casirivimab and Imdevimab are monoclonal antibodies that are specifically directed against the spike protein of SARS-CoV-2, and designed to block the virus' attachment and entry into human cells.  

Scaria also indicated the mutation may be associated with the ability to escape the immune response against the virus.

Allaying fears, immunologist Vineeta Bal noted that while there may be some setback in the use of commercial antibody cocktail due to the new variant, resistance to the therapy is not an indication of higher virulence or severity of a disease.  

“How transmissible this new variant is will be a crucial factor to determine its rapid spread or otherwise,” Bal, guest faculty at the Indian Institute of Science Education and Research, Pune, told PTI.  

She also noted that the quality and quantity of neutralising antibodies, responsible for defending cells from pathogens, generated in the individual infected with the new variant is unlikely to be affected because of the mutation.  

“Thus in individuals catching infection with the new variant, it may not be a matter worth worrying,” she added. 

Pulmonologist and medical researcher Anurag Agrawal concurred.  

“There is no cause of concern due to the new variant in India as of now,” Agrawal, the director of CSIR-IGIB, told PTI.

The scientist said the blood plasma from many fully vaccinated individuals will have to be tested against this variant to determine whether it shows any significant immune escape.  As the Delta variant continues to evolve and acquire new mutations, there is a lot of interest in understanding its evolution. He said SARS-CoV-2 has a nearly constant rate of acquiring genetic variants, and each variant has acquired additional variants in a stepwise fashion.

“Understanding this continued evolution is of great importance in mapping the evolutionary landscape of emerging variants. Largely the virus has tried to optimise for transmission and immune escape by step-wise acquisition of new mutations,” he added 

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News Network
March 28,2025

chaos.jpg

When the ground violently shook beneath his feet, Prem Kishore Mohanty, an Indian expatriate in Bangkok, was attending his five-year-old daughter's school sports day. What began as a routine event—children competing, parents cheering—quickly turned into a moment of panic as tremors struck.

"I felt my head spinning and had to sit down. The overhead lights swayed, and chairs moved," said Mr. Mohanty, 44. The school's PA system quickly announced an emergency evacuation, directing everyone to the outdoor field while warning against using nearby lanes lined with high-rise towers.

Water from rooftop swimming pools, including those at the InterContinental Bangkok, cascaded down buildings, as captured in viral videos.

Fear and Chaos as Bangkok Shakes
The 7.7-magnitude earthquake, with its epicenter in Myanmar, sent powerful tremors into Thailand, bringing Bangkok to an abrupt standstill. Public transport was suspended, traffic snarled, and people evacuated buildings, waiting anxiously for the all-clear.

Earthquakes are rare in Bangkok, a city more accustomed to heat and monsoons than seismic shocks. For the Mohanty family, who live in a high-rise apartment in Sukhumvit, confusion and fear gripped them as the evacuation began.

"It was terrifying. We were told to take the fire escape stairwell and wait outside. There was no time to think," Mr. Mohanty recalled.

Now safe, he remains shaken by the unexpected jolt that turned a normal day into a moment of chaos for his family and thousands across the city.

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News Network
March 30,2025

Eid al-Fitr 2025 was marked with grand celebrations across the Middle East, as millions of Muslims came together to pray, feast, and rejoice. However, amid the festivities in Saudi Arabia, the UAE, Qatar, and Kuwait, Gaza stood in mourning. The ongoing conflict and devastation in Palestine turned what is usually a time of joy into a period of sorrow and survival for many Palestinians. While some regions witnessed fireworks and public gatherings, Gaza endured airstrikes, hunger, and loss, painting a stark contrast to the celebrations elsewhere.

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Muslims attend mass Eid al-Fitr prayers marking the end of the holy fasting month of Ramadan in Dubai, United Arab Emirates, Sunday, March 30, 2025

Gaza: Eid Amid Destruction and Mourning

In Gaza, the usual festive spirit of Eid was shattered by grief and destruction. Israeli airstrikes claimed the lives of several civilians, including women and children, leaving families mourning rather than rejoicing.

The usually vibrant markets of Gaza, once filled with people buying sweets and new clothes for Eid, remained eerily silent. Many families had no food to prepare the traditional celebratory meals, as ongoing blockades and supply shortages have left residents struggling for survival.

President Mahmoud Abbas declared that this year's Eid celebrations should be limited to religious observances, acknowledging the suffering of the people. In place of festivities, prayers were held for the victims of the war, and aid organizations worked tirelessly to distribute basic necessities to displaced families.

Saudi Arabia: Grand Celebrations Despite Regional Tensions

In stark contrast, Saudi Arabia witnessed grand celebrations with large-scale public events, concerts, and fireworks. The General Entertainment Authority (GEA) organized festivities across Riyadh, Jeddah, and other major cities. The night skies were illuminated with dazzling fireworks in places such as Boulevard World (Riyadh), Jeddah Art Promenade, and Al-Khobar Corniche.

Despite the revelry, many Saudi citizens expressed solidarity with Palestinians, with social media campaigns and fundraising efforts aiming to support those suffering in Gaza.

United Arab Emirates: A Festival of Luxury and Giving

The UAE celebrated Eid al-Fitr with traditional prayers, family gatherings, and a wide range of entertainment events. Dubai and Abu Dhabi hosted special cultural performances, and malls offered discounts and attractions for families.

However, amidst the celebrations, many mosques in the UAE emphasized the importance of charity, urging people to contribute to humanitarian efforts in Gaza and other conflict zones.

Qatar: A Blend of Joy and Concern

Qatar marked the beginning of Eid on March 30, 2025, with three days of public holidays and an extended break for government employees. Doha’s Corniche and Katara Cultural Village became focal points for celebrations, with thousands gathering to enjoy fireworks and live performances.

Nevertheless, Qatari authorities and charities continued their relief efforts for Palestine, highlighting the contrast between the joyous Eid atmosphere at home and the suffering of their fellow Muslims in Gaza.

Kuwait: Extended Holidays and Reflection

In Kuwait, Eid holidays provided a nine-day break for many employees, allowing families to come together in celebration. Traditional meals and prayers remained central to the festivities, but Kuwaiti media and religious leaders also focused on the plight of Palestinians, urging the public to donate and raise awareness.

A Tale of Two Realities

Eid al-Fitr 2025 presented a stark contrast between different parts of the Muslim world. While countries like Saudi Arabia, the UAE, Qatar, and Kuwait indulged in celebrations, Gaza stood in ruins, mourning its dead and struggling to find basic resources.

The divide between those celebrating and those suffering was more evident than ever, making this Eid a time of reflection for many Muslims worldwide. The call for peace and justice in Palestine echoed throughout sermons and speeches, reminding the world that while the spirit of Eid is about joy and gratitude, it is also about unity, compassion, and standing with those in need.

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Agencies
March 26,2025

The airstrikes led by the United States have killed at least 25 civilians in Yemen over the past week, marking the deadliest week of bombing on the country since the final months of the Washington-backed Saudi war in January 2022.

In a report released on Tuesday, the Yemen Data Project said the 25 civilians were the victims of 38 US-led aerial assaults on March 15-21, adding that 28 people were also injured in the attacks.

The independent tracker also said that 21 out of the 38 US air raids hit non-military, civilian targets.

“Civilian targets hit included: a medical storage facility, a medical center, a school, a wedding hall, residential areas, a cotton gin facility, a health office, Bedouin tents, and Al-Eiman University,” it said.

The deadliest US strike in the first week of US bombing campaign struck a residential area in Yemen’s northwestern Sa'ada province, killing 10 civilians and wounding 11 others, among them children.

The US began bombing Yemen on March 15, a few days after Yemen resumed its operation against Israeli-linked ships in response to Israel’s Gaza aid blockade that violated a ceasefire with the Hamas resistance group.

The Yemeni Armed Forces began their anti-Israel naval campaign in November 2023, a month after the occupying regime waged a genocidal war on the Gaza Strip.

The Yemeni forces halted their attacks in solidarity with the Palestinians in January, when Israel accepted a three-phase Gaza ceasefire.

Two months later, however, Israel unilaterally broke the Gaza truce and resumed its brutal onslaught on the besieged territory.

On Tuesday, Yemeni media reported 17 US strikes on Sa'ada and two more on the nearby 'Amran province.

The reports said American warplanes carried out "aggressive air raids... causing material damage to citizens' property," but gave no details of casualties.

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