New covid-19 variant 'Delta plus' identified; Should India be worried?

Agencies
June 14, 2021

The highly transmissible Delta variant of SARS-CoV-2 has mutated further to form the ‘Delta plus’ or ‘AY.1’ variant but there is no immediate cause for concern in India as its incidence in the country is still low, scientists said.

The new Delta plus variant has been formed due to a mutation in the Delta or B.1.617.2 variant, first identified in India and one of the drivers of the deadly second wave. Though there is no indication yet of the severity of the disease due to the new variant, Delta plus is resistant to the monoclonal antibody cocktail treatment for Covid-19 recently authorised in India.

“One of the emerging variants is B.1.617.2.1 also known as AY.1 characterized by the acquisition of K417N mutation,” Vinod Scaria, clinician and scientist at Delhi’s CSIR-Institute of Genomics and Integrative Biology (IGIB), tweeted on Sunday.  

The mutation, he said, is in the spike protein of SARS-COV-2, which helps the virus enter and infect the human cells.  

According to Public Health England, 63 genomes of Delta (B.1.617.2) with the new K417N mutation have been identified so far on the global science initiative GISAID.  

In its latest report on coronavirus variants, updated till last Friday, the health agency said Delta plus was present in six genomes from India as of June 7.  

“The variant frequency for K417N is not much in India at this point in time. The sequences are mostly from Europe, Asia and America,” Scaria wrote on Twitter.  

The earliest sequence of this genome was found in Europe in late March this year.  

Noting that the travel histories for the variant are not readily available to make assumptions, Scaria said an important point to consider regarding K417N is the “evidence suggesting resistance to monoclonal antibodies Casirivimab and Imdevimab”.

This cocktail recently received emergency-use authorization in the country from the Central Drugs Standard Control Organisation. Drug majors Roche India and Ciplas have priced the antibody cocktail at a steep Rs 59,750 per dose.  

Similar to antibodies which are proteins that the body naturally produces to defend itself against the disease, monoclonal antibodies are artificially created in a lab and tailor-made to fight the disease they treat.  

Casirivimab and Imdevimab are monoclonal antibodies that are specifically directed against the spike protein of SARS-CoV-2, and designed to block the virus' attachment and entry into human cells.  

Scaria also indicated the mutation may be associated with the ability to escape the immune response against the virus.

Allaying fears, immunologist Vineeta Bal noted that while there may be some setback in the use of commercial antibody cocktail due to the new variant, resistance to the therapy is not an indication of higher virulence or severity of a disease.  

“How transmissible this new variant is will be a crucial factor to determine its rapid spread or otherwise,” Bal, guest faculty at the Indian Institute of Science Education and Research, Pune, told PTI.  

She also noted that the quality and quantity of neutralising antibodies, responsible for defending cells from pathogens, generated in the individual infected with the new variant is unlikely to be affected because of the mutation.  

“Thus in individuals catching infection with the new variant, it may not be a matter worth worrying,” she added. 

Pulmonologist and medical researcher Anurag Agrawal concurred.  

“There is no cause of concern due to the new variant in India as of now,” Agrawal, the director of CSIR-IGIB, told PTI.

The scientist said the blood plasma from many fully vaccinated individuals will have to be tested against this variant to determine whether it shows any significant immune escape.  As the Delta variant continues to evolve and acquire new mutations, there is a lot of interest in understanding its evolution. He said SARS-CoV-2 has a nearly constant rate of acquiring genetic variants, and each variant has acquired additional variants in a stepwise fashion.

“Understanding this continued evolution is of great importance in mapping the evolutionary landscape of emerging variants. Largely the virus has tried to optimise for transmission and immune escape by step-wise acquisition of new mutations,” he added 

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News Network
April 10,2025

Washington: In a move that stunned markets and political observers alike, US President Donald Trump on Wednesday announced a 90-day pause on his sweeping tariff regime—granting relief to all countries except China. Just a day earlier, such a reversal had seemed unimaginable.

Trump said the pause was prompted by the cooperative stance of over 75 nations, which had refrained from retaliating against his earlier tariffs. These countries, he claimed, chose negotiation over confrontation. During the pause, a reduced reciprocal tariff of 10% will be in place.

However, Trump made it clear that China would face no such leniency. Citing Beijing's alleged trade abuses and “lack of respect” for global markets, he announced an immediate hike in tariffs on Chinese imports to 125%, up from the earlier 104%.

“At some point, hopefully in the near future, China will realize that the days of ripping off the US and other countries is no longer sustainable or acceptable,” Trump wrote on Truth Social.

Despite repeatedly resisting pressure from within his own party and business circles to halt the tariff spree, Trump’s sudden pivot was reportedly triggered by alarm bells inside the US Treasury Department. According to CNN, Treasury Secretary Scott Bessent raised red flags about a dramatic selloff in the bond market, which, if left unchecked, could spiral into a financial crisis.

Speaking to the media after the announcement, Trump seemed to suggest that the decision came from instinct rather than strategy.

“We didn’t have access to lawyers… We wrote it up from our hearts. You have to be flexible,” he said.

The markets responded instantly. The Dow Jones Industrial Average surged over 2,500 points, while the Nasdaq jumped 12.2%, its best day in 24 years. The S&P 500 rose 6%, oil prices climbed more than 4%, and the dollar strengthened.

Impact on India

India, which had been hit with a 26% customized reciprocal tariff, saw its markets rattled in recent weeks. The pause offers a much-needed breather, as New Delhi works to finalize a multi-sectoral trade deal with Washington.

Ministry of External Affairs Spokesperson Randhir Jaiswal confirmed that talks are underway. “We hope to address these issues and conclude this agreement expeditiously,” he said, underlining the strong economic ties between the two nations.

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News Network
April 9,2025

Mangaluru: A routine midnight tea run turned into a horrifying tragedy when a motorcycle carrying three young men — in clear violation of traffic rules — slammed into an open divider on National Highway 66 at SKS Junction in the early hours of April 8. Two of them lost their lives, while the third is recovering from injuries.

The victims have been identified as Sankeerth, who was riding the motorcycle (KL-58-Q-6381), and Dhanurved C, the first pillion rider. Sibi Sam, the second pillion rider, was injured but survived the crash.

According to the FIR registered at the Traffic East Police Station (Crime No. 48/2025), the friends had set out from Lohith Nagar around 2:30 am, heading towards Pumpwell for tea. While Rohan Joby and Meghnath rode separately on a different bike (KL-13-AH-2388), Sankeerth was accompanied by two pillion riders — a clear case of triple riding, which is both illegal and dangerous.

As they sped along NH-66, Sankeerth reportedly lost control near SKS Junction and collided with the edge of an open road divider at approximately 2:50 am. The impact threw all three men onto the highway with violent force.

Sankeerth and Dhanurved suffered critical head and facial injuries and died while being rushed to the hospital. Sibi Sam is undergoing treatment for his injuries.

The FIR invokes Sections 281, 125(a), 106(1) of the Bharatiya Nyaya Sanhita, and 128(a) read with 177 of the Motor Vehicles Act, which include provisions related to rash driving and traffic violations.

The police have launched a full investigation. The accident has reignited public concern about reckless driving, triple riding, and the hazards posed by poorly maintained road dividers, especially during low-visibility hours.

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News Network
April 12,2025

Riyadh, April 12: In a welcome move for Indian expatriates and other foreign residents in Saudi Arabia, the Kingdom has introduced a new online service that allows residents to update their passport information without visiting the General Directorate of Passports (Jawazat). The service is available through the widely used Absher platform.

This initiative comes as a major time-saver for Indian expats, especially those renewing their passports, as it eliminates the need for lengthy in-person appointments and physical document submissions at Jawazat offices.

Who Can Use the Service?

The online update feature is available to expatriates aged 18 and above. Once a passport is renewed, Indian expats can log in to Absher (via their employers account), navigate to My Services, select Passport, and then access Resident Identity Services to update the relevant information.

A clear photo of the new passport must be uploaded. The system automatically extracts the passport number and expiry date using advanced digital recognition tools.

Before submitting, users are required to pledge that:

  • The old passport has not been lost.
  • There are no reports of absence from work.
  • There are no pending traffic violations linked to the resident's Iqama.
  • There are no security-related restrictions on the expat or the employer.

Important for Indian Families

If family members previously listed on the old passport have been issued individual passports, the online service cannot be used. In such cases, a personal visit to Jawazat is necessary to complete the update.

Likewise, if the passport is lost, the expat must report the loss and update information directly at the Jawazat office. Any misuse or incorrect submission will result in accountability under Saudi law, including potential charges of forgery.

Fee Details

To avail this convenience, a nominal fee of SR69 (including VAT) is applicable for each passport update request.

Why It Matters

With over 2 million Indians living and working in Saudi Arabia, this digital service is expected to ease the bureaucratic burden and save time for thousands of individuals who previously had to navigate crowded offices and long wait times. It also enhances accuracy and ensures smoother processing for both employees and employers.

Indian community associations have welcomed the move, calling it a step forward in digital convenience and administrative efficiency for expatriates.

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